2BUA

Crystal Structure Of Porcine Dipeptidyl Peptidase IV (Cd26) in Complex With a Low Molecular Weight Inhibitor.

Summary for 2BUA

Entry DOI	10.2210/pdb2bua/pdb
Related	1ORV 1ORW 2BUC
Descriptor	DIPEPTIDYL PEPTIDASE IV, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	hydrolase/inhibitor, dpp-iv, diabetes mellitus, drug design, hydrolase, serine protease, aminopeptidase, glycoprotein, protease, signal- anchor, transmembrane, complex (hydrolase-inhibitor), hydrolase-inhibitor complex
Biological source	SUS SCROFA (PIG)
Total number of polymer chains	4
Total formula weight	346324.44
Authors	Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.,Hill, O.,Matassa, V.G.,Metz, G.,Rummey, C.,Thiemann, M.,Edwards, P.J. (deposition date: 2005-06-09, release date: 2006-01-23, Last modification date: 2020-07-29)
Primary citation	Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.,Hill, O.,Matassa, V.G.,Metz, G.,Rummey, C.,Thiemann, M.,Edwards, P.J. The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors. Bioorg. Med. Chem. Lett., 16:1744-1748, 2006 Cited by PubMed: 16376544 DOI: 10.1016/j.bmcl.2005.11.103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation