3GY2
A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
Summary for 3GY2
Entry DOI | 10.2210/pdb3gy2/pdb |
Related | 3GY3 3GY4 3GY5 3GY6 3GY7 3GY8 |
Descriptor | Cationic trypsin, CALCIUM ION, BERENIL, ... (6 entities in total) |
Functional Keywords | bovine beta-trypsin, ligand, protein-ligand complex, protein-ligand interaction, calcium, digestion, disulfide bond, hydrolase, metal-binding, protease, secreted, serine protease, zymogen |
Biological source | Bos taurus (bovine,cow) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 24306.28 |
Authors | Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A.P. (deposition date: 2009-04-03, release date: 2010-03-23, Last modification date: 2011-07-13) |
Primary citation | Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A. Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol., 46:502-511, 2010 Cited by PubMed: 20356563DOI: 10.1016/j.ijbiomac.2010.03.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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