3GWT

Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor

Summary for 3GWT

• Entry DOI: 10.2210/pdb3gwt/pdb
• Related: 3FRG
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 6-{[3-(dimethylcarbamoyl)phenyl]sulfonyl}-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide, ZINC ION, ... (7 entities in total)
• Functional Keywords: pde, phosphodiesterase, camp, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41768.22

Authors

Somers, D.O.,Neu, M. (deposition date: 2009-04-01, release date: 2010-04-07, Last modification date: 2023-09-06)

• Primary citation: Woodrow, M.D.,Ballantine, S.P.,Barker, M.D.,Clarke, B.J.,Dawson, J.,Dean, T.W.,Delves, C.J.,Evans, B.,Gough, S.L.,Guntrip, S.B.,Holman, S.,Holmes, D.S.,Kranz, M.,Lindvaal, M.K.,Lucas, F.S.,Neu, M.,Ranshaw, L.E.,Solanke, Y.E.,Somers, D.O.,Ward, P.,Wiseman, J.O.; Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.; Bioorg.Med.Chem.Lett., 19:5261-5265, 2009; PubMed: 19656678; DOI: 10.1016/j.bmcl.2009.04.012

Experimental method

X-RAY DIFFRACTION (1.75 Å)