3GVU

The crystal structure of human ABL2 in complex with GLEEVEC

3GVU の概要

• エントリーDOI: 10.2210/pdb3gvu/pdb
• 関連するPDBエントリー: 1FPU
• 分子名称: Tyrosine-protein kinase ABL2, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total)
• 機能のキーワード: tyrosine kinase, abl, abelson murine leukemia viral oncogene, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton: P42684
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34530.56

構造登録者

Ugochukwu, E.,Salah, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Chaikuad, A.,Filippakopoulos, P.,Roos, A.,Pike, A.C.W.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-03-31, 公開日: 2009-04-21, 最終更新日: 2023-11-01)

• 主引用文献: Salah, E.,Ugochukwu, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Knapp, S.; The crystal structure of human ABL2 in complex with GLEEVEC; To be Published,

実験手法

X-RAY DIFFRACTION (2.05 Å)