3GT8

Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP

3GT8 の概要

• エントリーDOI: 10.2210/pdb3gt8/pdb
• 分子名称: Epidermal growth factor receptor, Unknown peptide, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: inactive kinase, dimer, alternative splicing, anti-oncogene, atp-binding, cell cycle, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 153562.26

構造登録者

Jura, N.,Endres, N.F.,Engel, K.,Deindl, S.,Das, R.,Lamers, M.H.,Wemmer, D.E.,Zhang, X.,Kuriyan, J. (登録日: 2009-03-27, 公開日: 2009-07-21, 最終更新日: 2024-02-21)

• 主引用文献: Jura, N.,Endres, N.F.,Engel, K.,Deindl, S.,Das, R.,Lamers, M.H.,Wemmer, D.E.,Zhang, X.,Kuriyan, J.; Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.; Cell(Cambridge,Mass.), 137:1293-1307, 2009; PubMed: 19563760; DOI: 10.1016/j.cell.2009.04.025

実験手法

X-RAY DIFFRACTION (2.955 Å)