3GS7
Human transthyretin (TTR) complexed with (E)-3-(2-methoxybenzylideneaminooxy)propanoic acid (inhibitor 13)
Summary for 3GS7
Entry DOI | 10.2210/pdb3gs7/pdb |
Related | 3GLZ 3GS0 3GS4 |
Descriptor | Transthyretin, 3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acid (3 entities in total) |
Functional Keywords | transthyretin, inhibitor, amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, polymorphism, retinol-binding, secreted, thyroid hormone, transport, vitamin a |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28001.17 |
Authors | Mohamedmohaideen, N.N.,Palaninathan, S.K.,Orlandini, E.,Sacchettini, J.C. (deposition date: 2009-03-26, release date: 2009-07-28, Last modification date: 2023-09-06) |
Primary citation | Palaninathan, S.K.,Mohamedmohaideen, N.N.,Orlandini, E.,Ortore, G.,Nencetti, S.,Lapucci, A.,Rossello, A.,Freundlich, J.S.,Sacchettini, J.C. Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. Plos One, 4:e6290-e6290, 2009 Cited by PubMed: 19621084DOI: 10.1371/journal.pone.0006290 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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