3GRG

Crystal structure of the F87M/L110M mutant of human transthyretin at pH 7.5

3GRG の概要

• エントリーDOI: 10.2210/pdb3grg/pdb
• 関連するPDBエントリー: 1f41 1gko 3dgd 3gps 3grb
• 分子名称: Transthyretin, ZINC ION, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: transthyretin, amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56684.27

構造登録者

Palmieri, L.C.,Freire, J.B.B.,Foguel, D.,Lima, L.M.T.R. (登録日: 2009-03-25, 公開日: 2010-04-07, 最終更新日: 2023-09-06)

• 主引用文献: Palmieri, L.de.C.,Lima, L.M.,Freire, J.B.,Bleicher, L.,Polikarpov, I.,Almeida, F.C.,Foguel, D.; Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.; J.Biol.Chem., 285:31731-31741, 2010; PubMed: 20659897; DOI: 10.1074/jbc.M110.157206

実験手法

X-RAY DIFFRACTION (1.9 Å)