3GRG

Crystal structure of the F87M/L110M mutant of human transthyretin at pH 7.5

Summary for 3GRG

Entry DOI	10.2210/pdb3grg/pdb
Related	1f41 1gko 3dgd 3gps 3grb
Descriptor	Transthyretin, ZINC ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	transthyretin, amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	4
Total formula weight	56684.27
Authors	Palmieri, L.C.,Freire, J.B.B.,Foguel, D.,Lima, L.M.T.R. (deposition date: 2009-03-25, release date: 2010-04-07, Last modification date: 2023-09-06)
Primary citation	Palmieri, L.de.C.,Lima, L.M.,Freire, J.B.,Bleicher, L.,Polikarpov, I.,Almeida, F.C.,Foguel, D. Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285:31731-31741, 2010 Cited by PubMed: 20659897 DOI: 10.1074/jbc.M110.157206 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation