3GPS
Crystal structure of the F87M/L110M mutant of human transthyretin at pH 5.5
Summary for 3GPS
Entry DOI | 10.2210/pdb3gps/pdb |
Related | 1F41 1GKO 3DGD 3grb 3grg |
Descriptor | Transthyretin, ZINC ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | transthyretin, amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, ligand binding protein, transport protein |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 4 |
Total formula weight | 57137.69 |
Authors | Palmieri, L.C.,Freire, J.B.B.,Foguel, D.,Lima, L.M.T.R. (deposition date: 2009-03-23, release date: 2010-04-07, Last modification date: 2023-09-06) |
Primary citation | Palmieri, L.de.C.,Lima, L.M.,Freire, J.B.,Bleicher, L.,Polikarpov, I.,Almeida, F.C.,Foguel, D. Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285:31731-31741, 2010 Cited by PubMed: 20659897DOI: 10.1074/jbc.M110.157206 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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