3GPW
Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: irreversible inhibitor ligand
Summary for 3GPW
Entry DOI | 10.2210/pdb3gpw/pdb |
Related | 1ryp 2fak 3GPJ 3GPT |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total) |
Functional Keywords | proteasome, ubiquitin, cancer therapy, immunology, time-dependent elimination of a defined leaving group, cytoplasm, hydrolase, nucleus, phosphoprotein, protease, threonine protease, isopeptide bond, ubl conjugation, zymogen |
Biological source | Saccharomyces cerevisiae (yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 705882.23 |
Authors | Groll, M.,Macherla, V.R.,Manam, R.R.,Arthur, K.A.M.,Potts, C.B. (deposition date: 2009-03-23, release date: 2009-09-15, Last modification date: 2023-09-20) |
Primary citation | Groll, M.,McArthur, K.A.,Macherla, V.R.,Manam, R.R.,Potts, B.C. Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition J.Med.Chem., 52:5420-5428, 2009 Cited by PubMed: 19678642DOI: 10.1021/jm900559x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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