3GPW

Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: irreversible inhibitor ligand

3GPW の概要

• エントリーDOI: 10.2210/pdb3gpw/pdb
• 関連するPDBエントリー: 1ryp 2fak 3GPJ 3GPT
• 分子名称: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• 機能のキーワード: proteasome, ubiquitin, cancer therapy, immunology, time-dependent elimination of a defined leaving group, cytoplasm, hydrolase, nucleus, phosphoprotein, protease, threonine protease, isopeptide bond, ubl conjugation, zymogen
• 由来する生物種: Saccharomyces cerevisiae (yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 705882.23

構造登録者

Groll, M.,Macherla, V.R.,Manam, R.R.,Arthur, K.A.M.,Potts, C.B. (登録日: 2009-03-23, 公開日: 2009-09-15, 最終更新日: 2023-09-20)

• 主引用文献: Groll, M.,McArthur, K.A.,Macherla, V.R.,Manam, R.R.,Potts, B.C.; Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition; J.Med.Chem., 52:5420-5428, 2009; PubMed: 19678642; DOI: 10.1021/jm900559x

実験手法

X-RAY DIFFRACTION (2.5 Å)