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3GPT

Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow substrate ligand

3GPT の概要
エントリーDOI10.2210/pdb3gpt/pdb
関連するPDBエントリー1ryp 2fak 3GPJ 3GPW
分子名称Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
機能のキーワードproteasome, ubiquitin, cancer therapy, inhibitor, immunology, time dependent leaving group elimination, cytoplasm, hydrolase, nucleus, phosphoprotein, protease, threonine protease, isopeptide bond, ubl conjugation, zymogen
由来する生物種Saccharomyces cerevisiae (yeast)
詳細
細胞内の位置Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
タンパク質・核酸の鎖数28
化学式量合計706002.27
構造登録者
Groll, M.,Macherla, V.R.,Manam, R.R.,Arthur, K.A.M.,Potts, C.B. (登録日: 2009-03-23, 公開日: 2009-09-15, 最終更新日: 2023-09-06)
主引用文献Groll, M.,McArthur, K.A.,Macherla, V.R.,Manam, R.R.,Potts, B.C.
Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52:5420-5428, 2009
Cited by
PubMed: 19678642
DOI: 10.1021/jm900559x
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.41 Å)
構造検証レポート
Validation report summary of 3gpt
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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