3GPQ
Crystal structure of macro domain of Chikungunya virus in complex with RNA
Summary for 3GPQ
Entry DOI | 10.2210/pdb3gpq/pdb |
Related | 3GPG 3GPO 3GQE |
Descriptor | Non-structural protein 3, RNA (5'-R(*AP*AP*A)-3') (3 entities in total) |
Functional Keywords | macro domain, x domain, chikungunya, alphavirus, virus, vizier. viral enzymes involved in replication, rna, atp-binding, cell membrane, endosome, helicase, hydrolase, lipoprotein, lysosome, membrane, methyltransferase, mrna capping, mrna processing, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, palmitate, phosphoprotein, protease, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, viral protein/rna, viral protein-rna complex |
Biological source | Chikungunya virus |
Cellular location | Non-structural polyprotein: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). P123: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). mRNA-capping enzyme nsP1: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Protease nsP2: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 3: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). RNA-directed RNA polymerase nsP4: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): Q8JUX6 |
Total number of polymer chains | 6 |
Total formula weight | 76425.81 |
Authors | Malet, H.,Jamal, S.,Coutard, B.,Canard, B. (deposition date: 2009-03-23, release date: 2009-07-21, Last modification date: 2023-09-06) |
Primary citation | Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B. The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket J.Virol., 83:6534-6545, 2009 Cited by PubMed: 19386706DOI: 10.1128/JVI.00189-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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