3GKY

The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape

Summary for 3GKY

Entry DOI	10.2210/pdb3gky/pdb
Related	1TRZ
Descriptor	Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
Functional Keywords	protein folding, er stress-associated, tr transition receptor binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted
Biological source	Sus scrofa (pig) More
Cellular location	Secreted: P01315 P01315
Total number of polymer chains	4
Total formula weight	11917.12
Authors	Liu, M.,Wan, Z.L.,Chu, Y.C.,Alddin, H.,Klaproth, B.,Weiss, M.A. (deposition date: 2009-03-11, release date: 2009-03-24, Last modification date: 2023-09-06)
Primary citation	Liu, M.,Wan, Z.L.,Chu, Y.C.,Aladdin, H.,Klaproth, B.,Choquette, M.,Hua, Q.X.,Mackin, R.B.,Rao, J.S.,De Meyts, P.,Katsoyannis, P.G.,Arvan, P.,Weiss, M.A. Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY. J.Biol.Chem., 284:35259-35272, 2009 Cited by PubMed: 19850922 DOI: 10.1074/jbc.M109.046888 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation