3GIS

Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin

3GIS の概要

• エントリーDOI: 10.2210/pdb3gis/pdb
• 分子名称: Prothrombin, Thrombomodulin, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: protein-protein complex, coagulation, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, egf-like domain, hydroxylation, membrane, receptor, thrombophilia, transmembrane, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Membrane; Single-pass type I membrane protein: P07204
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 146571.21

構造登録者

Adams, T.E.,Huntington, J.A. (登録日: 2009-03-06, 公開日: 2009-08-18, 最終更新日: 2023-11-01)

• 主引用文献: Adams, T.E.,Li, W.,Huntington, J.A.; Molecular basis of thrombomodulin activation of slow thrombin; J.Thromb.Haemost., 7:1688-1695, 2009; PubMed: 19656282; DOI: 10.1111/j.1538-7836.2009.03563.x

実験手法

X-RAY DIFFRACTION (2.4 Å)