3GHT

Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Third stage of radiation damage.

3GHT の概要

• エントリーDOI: 10.2210/pdb3ght/pdb
• 関連するPDBエントリー: 1US0 2I16 2I17 2pev 2pf8 2pfh 3GHR 3GHS 3GHU
• 分子名称: Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, acetylation, cataract, cytoplasm, nadp, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37252.12

構造登録者

Petrova, T.,Ginell, S.,Hazemann, I.,Mitschler, A.,Podjarny, A.,Joachimiak, A. (登録日: 2009-03-04, 公開日: 2009-03-24, 最終更新日: 2023-09-06)

• 主引用文献: Petrova, T.,Lunin, V.Y.,Ginell, S.,Hazemann, I.,Lazarski, K.,Mitschler, A.,Podjarny, A.,Joachimiak, A.; X-ray-radiation-induced cooperative atomic movements in protein.; J.Mol.Biol., 387:1092-1105, 2009; PubMed: 19233199; DOI: 10.1016/j.jmb.2009.02.030

実験手法

X-RAY DIFFRACTION (1.1 Å)