3GHS

Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Second stage of radiation damage.

Summary for 3GHS

Entry DOI	10.2210/pdb3ghs/pdb
Related	1US0 2I16 2I17 2pev 2pf8 2pfh 3GHR 3GHT 3GHU
Descriptor	Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ... (5 entities in total)
Functional Keywords	oxidoreductase, acetylation, cataract, cytoplasm, nadp, phosphoprotein, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37252.12
Authors	Petrova, T.,Ginell, S.,Hazemann, I.,Mitschler, A.,Podjarny, A.,Joachimiak, A. (deposition date: 2009-03-04, release date: 2009-03-24, Last modification date: 2023-09-06)
Primary citation	Petrova, T.,Lunin, V.Y.,Ginell, S.,Hazemann, I.,Lazarski, K.,Mitschler, A.,Podjarny, A.,Joachimiak, A. X-ray-radiation-induced cooperative atomic movements in protein. J.Mol.Biol., 387:1092-1105, 2009 Cited by PubMed: 19233199 DOI: 10.1016/j.jmb.2009.02.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation