3GGU

HIV PR drug resistant patient's variant in complex with darunavir

Summary for 3GGU

• Entry DOI: 10.2210/pdb3ggu/pdb
• Related: 3GGT
• Descriptor: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• Functional Keywords: darunvir, resistance, mutation score, hiv protease, tmc-114, hydrolase
• Biological source: Human immunodeficiency virus type 1 (BRU ISOLATE)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22455.06

Authors

Saskova, K.G.,Brynda, J.,Rezacova, P. (deposition date: 2009-03-02, release date: 2009-08-11, Last modification date: 2023-09-06)

• Primary citation: Saskova, K.G.,Kozisek, M.,Rezacova, P.,Brynda, J.,Yashina, T.,Kagan, R.M.,Konvalinka, J.; Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir.; J.Virol., 83:8810-8818, 2009; PubMed: 19535439; DOI: 10.1128/JVI.00451-09

Experimental method

X-RAY DIFFRACTION (1.8 Å)