3GGU
HIV PR drug resistant patient's variant in complex with darunavir
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protease | polymer | 99 | 10953.7 | 2 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus type 1 (BRU ISOLATE) | |
2 | B | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
3 | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
PDB | External Database | Details |
---|---|---|
Ile 10 | Leu 510 | engineered mutation |
Val 13 | Ile 513 | engineered mutation |
Glu 16 | Gly 516 | engineered mutation |
Phe 33 | Leu 533 | engineered mutation |
Leu 36 | Met 536 | engineered mutation |
Thr 37 | Ser 537 | engineered mutation |
Ser 39 | Pro 539 | engineered mutation |
Arg 45 | Lys 545 | engineered mutation |
Leu 46 | Met 546 | engineered mutation |
Val 54 | Ile 554 | engineered mutation |
Arg 55 | Lys 555 | engineered mutation |
Val 62 | Ile 562 | engineered mutation |
Pro 63 | Leu 563 | engineered mutation |
Val 71 | Ala 571 | engineered mutation |
Asp 73 | Gly 573 | engineered mutation |
Thr 82 | Val 582 | engineered mutation |
Val 84 | Ile 584 | engineered mutation |
Val 89 | Leu 589 | engineered mutation |
Met 90 | Leu 590 | engineered mutation |
Leu 93 | Ile 593 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21907.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 547.7 | |
All* | Total formula weight | 22455.1 |