3GEQ
Structural basis for the chemical rescue of Src kinase activity
Summary for 3GEQ
Entry DOI | 10.2210/pdb3geq/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total) |
Functional Keywords | kinase, chemical rescue, pp2, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase |
Biological source | Gallus gallus (bantam,chickens) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 65886.63 |
Authors | Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A. (deposition date: 2009-02-25, release date: 2009-04-28, Last modification date: 2023-09-06) |
Primary citation | Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A. Comparative analysis of mutant tyrosine kinase chemical rescue. Biochemistry, 48:3378-3386, 2009 Cited by PubMed: 19260709DOI: 10.1021/bi900057g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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