3GDH

Methyltransferase domain of human Trimethylguanosine Synthase 1 (TGS1) bound to m7GTP and adenosyl-homocysteine (active form)

3GDH の概要

• エントリーDOI: 10.2210/pdb3gdh/pdb
• 分子名称: Trimethylguanosine synthase homolog, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total)
• 機能のキーワード: m7g, cap, dimethyltransferase, usnrna, snorna, telomerase, cytoplasm, methyltransferase, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q96RS0
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 83379.70

構造登録者

Monecke, T.,Dickmanns, A.,Ficner, R. (登録日: 2009-02-24, 公開日: 2009-06-23, 最終更新日: 2024-02-21)

• 主引用文献: Monecke, T.,Dickmanns, A.,Ficner, R.; Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1.; Nucleic Acids Res., 37:3865-3877, 2009; PubMed: 19386620; DOI: 10.1093/nar/gkp249

実験手法

X-RAY DIFFRACTION (2 Å)