3GCW

PCSK9:EGFA(H306Y)

3GCW の概要

• エントリーDOI: 10.2210/pdb3gcw/pdb
• 関連するPDBエントリー: 3GCX
• 分子名称: Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, ldl, lipid transport, membrane, receptor, transmembrane, transport, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: Q8NBP7 Q8NBP7; Cell membrane; Single-pass type I membrane protein: P01130
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 77882.87

構造登録者

Kwon, H.J. (登録日: 2009-02-22, 公開日: 2009-03-03, 最終更新日: 2023-09-06)

• 主引用文献: McNutt, M.C.,Kwon, H.J.,Chen, C.,Chen, J.R.,Horton, J.D.,Lagace, T.A.; Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.; J.Biol.Chem., 284:10561-10570, 2009; PubMed: 19224862; DOI: 10.1074/jbc.M808802200

実験手法

X-RAY DIFFRACTION (2.7 Å)