3G76
Crystal structure of XIAP-BIR3 in complex with a bivalent compound
Summary for 3G76
Entry DOI | 10.2210/pdb3g76/pdb |
Related | 1G73 2JK7 3EYL |
Descriptor | Baculoviral IAP repeat-containing protein 4, ZINC ION, 1,1'-{hexa-2,4-diyne-1,6-diylbis[oxy{(2S,3R)-2-[(N-methyl-L-alanyl)amino]-1-oxobutane-3,1-diyl}(2S)pyrrolidine-1,2-diylmethanediyl]}bis[5-(phenylsulfanyl)-1H-tetrazole], ... (4 entities in total) |
Functional Keywords | apoptosis, iap, smacdiablo, peptidomimetics, pro-apoptotic drugs, cytoplasm, ligase, metal-binding, phosphoprotein, polymorphism, protease inhibitor, thiol protease inhibitor, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P98170 |
Total number of polymer chains | 8 |
Total formula weight | 121257.88 |
Authors | Cossu, F.,Milani, M.,Mastrangelo, E.,Bolognesi, M. (deposition date: 2009-02-09, release date: 2009-05-12, Last modification date: 2023-11-01) |
Primary citation | Cossu, F.,Milani, M.,Mastrangelo, E.,Vachette, P.,Servida, F.,Lecis, D.,Canevari, G.,Delia, D.,Drago, C.,Rizzo, V.,Manzoni, L.,Seneci, P.,Scolastico, C.,Bolognesi, M. Structural basis for bivalent smac-mimetics recognition in the IAP protein family J.Mol.Biol., 392:630-644, 2009 Cited by PubMed: 19393243DOI: 10.1016/j.jmb.2009.04.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report