3G76
Crystal structure of XIAP-BIR3 in complex with a bivalent compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Baculoviral IAP repeat-containing protein 4 | polymer | 122 | 14122.6 | 8 | UniProt (P98170) Pfam (PF00653) | Homo sapiens (human) | E3 ubiquitin-protein ligase XIAP, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP |
| 2 | I, K, M, O, Q... (A, B, C, D, E...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | J, L, N, P, R... (A, B, C, D, E...) | 1,1'-{hexa-2,4-diyne-1,6-diylbis[oxy{(2S,3R)-2-[(N-methyl-L-alanyl)amino]-1-oxobutane-3,1-diyl}(2S)pyrrolidine-1,2-diylmethanediyl]}bis[5-(phenylsulfanyl)-1H-tetrazole] | non-polymer | 969.2 | 8 | Chemie (CZ3) PubChem (25123914) PubChem (57939926) PubChem (72784477) PubChem (57986968) PubChem (59018565) PubChem (71454063) PubChem (122517984) PubChem (6918787) PubChem (126570788) PubChem (11286117) PubChem (11355097) PubChem (143102997) | |||
| 4 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 505 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 241 - 356 (UniProt: P98170)
| PDB | External Database | Details |
|---|---|---|
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
| His 361 | - | expression tag |
| His 362 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 112981.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 8276.8 | |
| All* | Total formula weight | 121257.9 |
