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3G6J

C3b in complex with a C3b specific Fab

Summary for 3G6J
Entry DOI10.2210/pdb3g6j/pdb
Related2I07 2ICF
DescriptorComplement C3 beta chain, Complement C3 alpha chain, Fab light chain, ... (5 entities in total)
Functional Keywordscomplement, c3b, fab, antibody:antigen, age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, glycoprotein, immune response, inflammatory response, innate immunity, phosphoprotein, secreted, thioester bond, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P01024 P01024
Total number of polymer chains8
Total formula weight445149.84
Authors
Wiesmann, C. (deposition date: 2009-02-06, release date: 2009-03-10, Last modification date: 2023-09-06)
Primary citationKatschke, K.J.,Stawicki, S.,Yin, J.,Steffek, M.,Xi, H.,Sturgeon, L.,Hass, P.E.,Loyet, K.M.,Deforge, L.,Wu, Y.,van Lookeren Campagne, M.,Wiesmann, C.
Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284:10473-10479, 2009
Cited by
PubMed: 19196712
DOI: 10.1074/jbc.M809106200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

217705

건을2024-03-27부터공개중

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