3G6J

C3b in complex with a C3b specific Fab

3G6J の概要

• エントリーDOI: 10.2210/pdb3g6j/pdb
• 関連するPDBエントリー: 2I07 2ICF
• 分子名称: Complement C3 beta chain, Complement C3 alpha chain, Fab light chain, ... (5 entities in total)
• 機能のキーワード: complement, c3b, fab, antibody:antigen, age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, glycoprotein, immune response, inflammatory response, innate immunity, phosphoprotein, secreted, thioester bond, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01024 P01024
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 445149.84

構造登録者

Wiesmann, C. (登録日: 2009-02-06, 公開日: 2009-03-10, 最終更新日: 2023-09-06)

• 主引用文献: Katschke, K.J.,Stawicki, S.,Yin, J.,Steffek, M.,Xi, H.,Sturgeon, L.,Hass, P.E.,Loyet, K.M.,Deforge, L.,Wu, Y.,van Lookeren Campagne, M.,Wiesmann, C.; Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement; J.Biol.Chem., 284:10473-10479, 2009; PubMed: 19196712; DOI: 10.1074/jbc.M809106200

実験手法

X-RAY DIFFRACTION (3.1 Å)