3G6E

Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit

Summary for 3G6E

Entry DOI	10.2210/pdb3g6e/pdb
Related	3G4S 3G71
Descriptor	23S ribosomal RNA, 50S ribosomal protein L11P, 50S ribosomal protein L13P, ... (39 entities in total)
Functional Keywords	large ribosomal subunit, antibiotic specificity, homoharringtonine, haloarcula marismortui, ribonucleoprotein, ribosomal protein, rna-binding, rrna-binding, trna-binding, metal-binding, zinc-finger, ribosome
Biological source	Haloarcula marismortui More
Cellular location	Cytoplasm : P12743
Total number of polymer chains	31
Total formula weight	1461627.50
Authors	Gurel, G.,Blaha, G.,Moore, P.B.,Steitz, T.A. (deposition date: 2009-02-06, release date: 2009-04-28, Last modification date: 2023-09-06)
Primary citation	Gurel, G.,Blaha, G.,Moore, P.B.,Steitz, T.A. U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J.Mol.Biol., 389:146-156, 2009 Cited by PubMed: 19362093 DOI: 10.1016/j.jmb.2009.04.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation