3G6E
Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 23S ribosomal RNA | polymer | 2923 | 946463.5 | 1 | GenBank (55229667) | Haloarcula marismortui | |
| 2 | B (A) | 50S ribosomal protein L2P | polymer | 237 | 24980.3 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) | Haloarcula marismortui | Hmal2, Hl4 |
| 3 | C (B) | 50S ribosomal protein L3P | polymer | 337 | 37265.2 | 1 | UniProt (P20279) Pfam (PF00297) | Haloarcula marismortui | Hmal3, Hl1 |
| 4 | D (C) | 50S ribosomal protein L4P | polymer | 246 | 26457.1 | 1 | UniProt (P12735) Pfam (PF00573) | Haloarcula marismortui | Hmal4, Hl6 |
| 5 | E (D) | 50S ribosomal protein L5P | polymer | 177 | 19551.7 | 1 | UniProt (P14124) Pfam (PF00281) Pfam (PF00673) | Haloarcula marismortui | Hmal5, Hl13 |
| 6 | F (E) | 50S ribosomal protein L6P | polymer | 172 | 19316.0 | 1 | UniProt (P14135) Pfam (PF00347) | Haloarcula marismortui | Hmal6, Hl10 |
| 7 | G (F) | 50S ribosomal protein L7Ae | polymer | 119 | 12660.7 | 1 | UniProt (P12743) Pfam (PF01248) | Haloarcula marismortui | Hs6 |
| 8 | H (G) | 50S ribosomal protein L10E | polymer | 348 | 37169.8 | 1 | UniProt (P15825) Pfam (PF00466) Pfam (PF17777) | Haloarcula marismortui | Ribosomal protein L10, Acidic ribosomal protein P0 homolog, L10E, HMal10 |
| 9 | I (H) | 50S ribosomal protein L10e | polymer | 177 | 19942.7 | 1 | UniProt (P60617) Pfam (PF00252) | Haloarcula marismortui | |
| 10 | J (I) | 50S ribosomal protein L11P | polymer | 70 | 7408.1 | 1 | UniProt (P14122) Pfam (PF00298) | Haloarcula marismortui | Hmal11 |
| 11 | K (J) | 50S ribosomal protein L13P | polymer | 142 | 15931.8 | 1 | UniProt (P29198) Pfam (PF00572) | Haloarcula marismortui | Hmal13 |
| 12 | L (K) | 50S ribosomal protein L14P | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) | Haloarcula marismortui | Hmal14, Hl27 |
| 13 | M (L) | 50S ribosomal protein L15P | polymer | 165 | 18005.4 | 1 | UniProt (P12737) Pfam (PF00828) | Haloarcula marismortui | Hmal15, Hl9 |
| 14 | N (M) | 50S ribosomal protein L15e | polymer | 194 | 22143.9 | 1 | UniProt (P60618) Pfam (PF00827) | Haloarcula marismortui | 50S ribosomal protein LC12 |
| 15 | O (N) | 50S ribosomal protein L18P | polymer | 186 | 20509.7 | 1 | UniProt (P14123) Pfam (PF17144) | Haloarcula marismortui | Hmal18, Hl12 |
| 16 | P (O) | 50S ribosomal protein L18e | polymer | 115 | 12307.7 | 1 | UniProt (P12733) Pfam (PF00828) | Haloarcula marismortui | Hl29, L19 |
| 17 | Q (P) | 50S ribosomal protein L19e | polymer | 143 | 16169.9 | 1 | UniProt (P14119) Pfam (PF01280) Pfam (PF25476) | Haloarcula marismortui | Hmal19, Hl24 |
| 18 | R (Q) | 50S ribosomal protein L21e | polymer | 95 | 10436.6 | 1 | UniProt (P12734) Pfam (PF01157) | Haloarcula marismortui | Hl31 |
| 19 | S (R) | 50S ribosomal protein L22P | polymer | 150 | 16363.3 | 1 | UniProt (P10970) Pfam (PF00237) | Haloarcula marismortui | Hmal22, Hl23 |
| 20 | T (S) | 50S ribosomal protein L23P | polymer | 81 | 9178.0 | 1 | UniProt (P12732) Pfam (PF00276) | Haloarcula marismortui | Hmal23, Hl25, L21 |
| 21 | U (T) | 50S ribosomal protein L24P | polymer | 119 | 13539.8 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) | Haloarcula marismortui | Hmal24, Hl16, Hl15 |
| 22 | V (U) | 50S ribosomal protein L24e | polymer | 53 | 5919.4 | 1 | UniProt (P14116) Pfam (PF01246) | Haloarcula marismortui | Hl21/Hl22 |
| 23 | W (V) | 50S ribosomal protein L29P | polymer | 65 | 7145.1 | 1 | UniProt (P10971) Pfam (PF00831) | Haloarcula marismortui | Hmal29, Hl33 |
| 24 | X (W) | 50S ribosomal protein L30P | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) | Haloarcula marismortui | Hmal30, Hl20, Hl16 |
| 25 | Y (X) | 50S ribosomal protein L31e | polymer | 82 | 9315.5 | 1 | UniProt (P18138) Pfam (PF01198) | Haloarcula marismortui | L34, Hl30 |
| 26 | Z (Y) | 50S ribosomal protein L32e | polymer | 142 | 16079.0 | 1 | UniProt (P12736) Pfam (PF01655) | Haloarcula marismortui | Hl5 |
| 27 | AA (Z) | 50S ribosomal protein L37Ae | polymer | 73 | 8224.1 | 1 | UniProt (P60619) Pfam (PF01780) | Haloarcula marismortui | |
| 28 | BA (1) | 50S ribosomal protein L37e | polymer | 56 | 6199.0 | 1 | UniProt (P32410) Pfam (PF01907) | Haloarcula marismortui | L35e |
| 29 | CA (2) | 50S ribosomal protein L39e | polymer | 50 | 6133.1 | 1 | UniProt (P22452) Pfam (PF00832) | Haloarcula marismortui | Hl39e, Hl46e |
| 30 | DA (3) | 50S ribosomal protein L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) | Haloarcula marismortui | La, Hla |
| 31 | EA (9) | 5S ribosomal RNA | polymer | 122 | 39303.4 | 1 | GenBank (6468293) | Haloarcula marismortui | |
| 32 | AB, AC, AD, BB, BC... (0, A, T, B, Y...) | MAGNESIUM ION | non-polymer | 24.3 | 93 | Chemie (MG) PubChem (888) | |||
| 33 | MD, ND (0) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) PubChem (813) | |||
| 34 | AE, AF, AG, AL, BE... (0, R, S, C, J...) | SODIUM ION | non-polymer | 23.0 | 75 | Chemie (NA) PubChem (923) | |||
| 35 | BL, CG, DG, DK, EG... (R, 0, A, B, Y...) | CHLORIDE ION | non-polymer | 35.5 | 22 | Chemie (CL) PubChem (312) | |||
| 36 | AH, AI, AJ, AK, BH... (0, R, A, S, B...) | STRONTIUM ION | non-polymer | 87.6 | 108 | Chemie (SR) PubChem (104798) | |||
| 37 | BK (0) | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine | non-polymer | 545.6 | 1 | Chemie (HMT) PubChem (3628) PubChem (285033) PubChem (45356872) PubChem (71211769) PubChem (53298607) PubChem (58786313) PubChem (60128438) PubChem (56841046) PubChem (68337922) PubChem (60128444) PubChem (70826802) PubChem (70826803) PubChem (71296925) PubChem (5458297) PubChem (72332) PubChem (6604865) PubChem (90392075) PubChem (10951700) PubChem (92850103) PubChem (92850104) PubChem (93956055) PubChem (93956056) PubChem (93956058) PubChem (14368099) PubChem (14368100) PubChem (93956057) PubChem (118911842) PubChem (138107280) PubChem (140440283) | |||
| 38 | GL, JL, KL, NL, XK (U, Z, 1, 3, O) | CADMIUM ION | non-polymer | 112.4 | 5 | Chemie (CD) PubChem (31193) | |||
| 39 | AM, AN, BM, BN, CM... (A, 1, B, 2, C...) | water | water | 18.0 | 7823 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1446214.1 | |
| Non-Polymers* | Number of molecules | 306 |
| Total formula weight | 15413.4 | |
| All* | Total formula weight | 1461627.5 |
