3G5U

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Summary for 3G5U

• Entry DOI: 10.2210/pdb3g5u/pdb
• Related: 3G60 3G61
• Descriptor: Multidrug resistance protein 1a, MERCURY (II) ION (2 entities in total)
• Functional Keywords: p-glycoprotein, multidrug resistance, pgp, cyclic peptide, membrane protein
• Biological source: Mus musculus (mouse)
• Total number of polymer chains: 2
• Total formula weight: 286138.77

Authors

Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G. (deposition date: 2009-02-05, release date: 2009-03-24, Last modification date: 2024-02-21)

• Primary citation: Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G.; Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.; Science, 323:1718-1722, 2009; PubMed: 19325113; DOI: 10.1126/science.1168750

Experimental method

X-RAY DIFFRACTION (3.8 Å)