3G5U

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Multidrug resistance protein 1a	polymer	1284	141865.8	2	UniProt (Q5I1Y5) Pfam (PF00664) Pfam (PF00005) UniProt (by SIFTS) (P21447)	Mus musculus (mouse)	MCG1178
2	C, D, E, F, G... (A, B)	MERCURY (II) ION	non-polymer		200.6	12	Chemie (HG)

Sequence modifications

A, B: 1 - 1276 (UniProt: Q5I1Y5)

PDB	External Database	Details
Ala 952	Cys 952	engineered mutation
Tyr 1277	-	expression tag
Val 1278	-	expression tag
His 1279	-	expression tag
His 1280	-	expression tag
His 1281	-	expression tag
His 1282	-	expression tag
His 1283	-	expression tag
His 1284	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	283731.7
Non-Polymers*	Number of molecules	12
	Total formula weight	2407.1
All*	Total formula weight	286138.8

*Water molecules are not included.