3G42

Crystal Structure of TACE with Tryptophan Sulfonamide Derivative Inhibitor

3G42 の概要

• エントリーDOI: 10.2210/pdb3g42/pdb
• 関連するPDBエントリー: 1BKC 1ZXC 2A8H 2I47
• 分子名称: ADAM 17, N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan, ZINC ION, ... (4 entities in total)
• 機能のキーワード: tace/adam-17, tace-inhibitor complex, zn-endopeptidase, alternative splicing, cleavage on pair of basic residues, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, polymorphism, protease, sh3-binding, transmembrane, zinc, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P78536
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132321.05

構造登録者

Xu, W.,Park, K.,Gopalsamy, A.,Aplasca, A.,Zhang, Y.H.,Levin, J.I. (登録日: 2009-02-03, 公開日: 2009-05-19, 最終更新日: 2024-10-09)

主引用文献

Park, K.,Gopalsamy, A.,Aplasca, A.,Ellingboe, J.W.,Xu, W.,Zhang, Y.,Levin, J.I.
Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg.Med.Chem., 17:3857-3865, 2009

PubMed Abstract: A novel series of non-hydroxamate tryptophan sulfonamide derivatives containing a butynyloxy P1' moiety was identified as inhibitors of TNF-alpha converting enzyme (TACE). The structure-activity relationship of the series was examined via substitution on the tryptophan indole ring. Of the compounds investigated, 2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-methoxybenzyl)-1H-indol-3-yl)propanoic acid (12p) has the best in vitro potency against isolated TACE enzyme with an IC(50) of 80 nM. Compound 12p also shows good selectivity over MMP-1, -13, -14.

PubMed: 19410464
DOI: 10.1016/j.bmc.2009.04.033

実験手法

X-RAY DIFFRACTION (2.1 Å)