3G15

Crystal structure of human choline kinase alpha in complex with hemicholinium-3 and ADP

Replaces:  3F2S

Summary for 3G15

• Entry DOI: 10.2210/pdb3g15/pdb
• Related: 3F2S
• Descriptor: Choline kinase alpha, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: non-protein kinase, choline kinase, structural genomics consortium, sgc, hemicholinium-3, kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 95685.78

Authors

Hong, B.S.,Tempel, W.,Rabeh, W.M.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.W.,Structural Genomics Consortium (SGC) (deposition date: 2009-01-29, release date: 2009-02-10, Last modification date: 2023-09-06)

• Primary citation: Hong, B.S.,Allali-Hassani, A.,Tempel, W.,Finerty, P.J.,Mackenzie, F.,Dimov, S.,Vedadi, M.,Park, H.W.; Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.; J.Biol.Chem., 285:16330-16340, 2010; PubMed: 20299452; DOI: 10.1074/jbc.M109.039024

Experimental method

X-RAY DIFFRACTION (1.7 Å)