3G0X

Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5

3G0X の概要

• エントリーDOI: 10.2210/pdb3g0x/pdb
• 関連するPDBエントリー: 3F1Q 3FJ6 3FJL 3G0U
• 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (6 entities in total)
• 機能のキーワード: beta barrel, tim barrel, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, polymorphism, pyrimidine biosynthesis, transit peptide
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion inner membrane; Single-pass membrane protein: Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40869.38

構造登録者

Davies, M.,Heikkila, T.,McConkey, G.A.,Fishwick, C.W.G.,Parsons, M.R.,Johnson, A.P. (登録日: 2009-01-29, 公開日: 2009-06-09, 最終更新日: 2024-03-20)

• 主引用文献: Davies, M.,Heikkila, T.,McConkey, G.A.,Fishwick, C.W.G.,Parsons, M.R.,Johnson, A.P.; Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases; J.Med.Chem., 52:2683-2693, 2009; PubMed: 19351152; DOI: 10.1021/jm800963t

実験手法

X-RAY DIFFRACTION (1.8 Å)