3FYP

Crystal structure of the quadruple mutant (N23C/C246S/D247E/P249A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis

3FYP の概要

• エントリーDOI: 10.2210/pdb3fyp/pdb
• 関連するPDBエントリー: 2qkf
• 分子名称: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase, CHLORIDE ION, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: manno-octulosonate, synthase, lipopolysaccharide, kdop, kdo8 kdops, kdo8ps, tim barrel, biosynthesis, transferase, lyase, lipopolysaccharide biosynthesis
• 由来する生物種: Neisseria meningitidis serogroup B
• 細胞内の位置: Cytoplasm (By similarity): Q9JZ55
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122445.22

構造登録者

Jameson, G.B.,Parker, E.J.,Cochrane, F.P.,Patchett, M.L. (登録日: 2009-01-22, 公開日: 2009-03-31, 最終更新日: 2023-09-06)

• 主引用文献: Cochrane, F.C.,Cookson, T.V.,Jameson, G.B.,Parker, E.J.; Reversing evolution: re-establishing obligate metal ion dependence in a metal-independent KDO8P synthase; J.Mol.Biol., 390:646-661, 2009; PubMed: 19447118; DOI: 10.1016/j.jmb.2009.05.014

実験手法

X-RAY DIFFRACTION (1.85 Å)