3FY8

Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101

3FY8 の概要

• エントリーDOI: 10.2210/pdb3fy8/pdb
• 関連するPDBエントリー: 3FY9 3FYV 3FYW
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: dhfr, nadp, one-carbon metabolism, oxidoreductase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19260.56

構造登録者

Oefner, C.,Dale, G.E. (登録日: 2009-01-22, 公開日: 2009-08-04, 最終更新日: 2024-05-29)

• 主引用文献: Oefner, C.,Parisi, S.,Schulz, H.,Lociuro, S.,Dale, G.E.; Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus; Acta Crystallogr.,Sect.D, 65:751-757, 2009; PubMed: 19622858; DOI: 10.1107/S0907444909013936

実験手法

X-RAY DIFFRACTION (2.2 Å)