3FY9

Staph. aureus DHFR F98Y complexed with AR-102

Summary for 3FY9

Entry DOI	10.2210/pdb3fy9/pdb
Related	3FY8 3FYV 3FYW
Descriptor	Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	dhfr, ar-102, oxidoreductase, nadp, one-carbon metabolism
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19258.54
Authors	Oefner, C. (deposition date: 2009-01-22, release date: 2009-08-04, Last modification date: 2023-11-01)
Primary citation	Oefner, C.,Parisi, S.,Schulz, H.,Lociuro, S.,Dale, G.E. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus Acta Crystallogr.,Sect.D, 65:751-757, 2009 Cited by PubMed: 19622858 DOI: 10.1107/S0907444909013936 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation