3FYV

Staph. aureus DHFR complexed with NADPH and AR-102

Summary for 3FYV

Entry DOI	10.2210/pdb3fyv/pdb
Related	3FY8 3FY9 3FYW
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	dhfr, staph.aureus, ar-102, oxidoreductase, nadp, one-carbon metabolism
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19244.56
Authors	Oefner, C. (deposition date: 2009-01-23, release date: 2009-08-04, Last modification date: 2024-03-20)
Primary citation	Oefner, C.,Parisi, S.,Schulz, H.,Lociuro, S.,Dale, G.E. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus Acta Crystallogr.,Sect.D, 65:751-757, 2009 Cited by PubMed: 19622858 DOI: 10.1107/S0907444909013936 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation