3FYW
Staph. aureus DHFR complexed with NADPH and AR-101
Summary for 3FYW
Entry DOI | 10.2210/pdb3fyw/pdb |
Related | 3FY8 3FY9 3FYV |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, ... (4 entities in total) |
Functional Keywords | staph. aureus dhfr, ar-101, oxidoreductase, nadp, one-carbon metabolism |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 19244.56 |
Authors | Oefner, C. (deposition date: 2009-01-23, release date: 2009-08-04, Last modification date: 2023-11-01) |
Primary citation | Oefner, C.,Parisi, S.,Schulz, H.,Lociuro, S.,Dale, G.E. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus Acta Crystallogr.,Sect.D, 65:751-757, 2009 Cited by PubMed: 19622858DOI: 10.1107/S0907444909013936 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report