3FXX
Human EphA3 Kinase and Juxtamembrane Region Bound to Substrate KQWDNYE[pTyr]IW
Summary for 3FXX
Entry DOI | 10.2210/pdb3fxx/pdb |
Related | 1IR3 2GSF 2QOC 3FY2 |
Descriptor | Ephrin type-A receptor 3, peptide substrate, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | receptor tyrosine kinase, juxtamembrane segment, structural genomics, peptide co-crystal structure, substrate complex, structural genomics consortium, sgc, atp-binding, cell membrane, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P29320 |
Total number of polymer chains | 2 |
Total formula weight | 43875.76 |
Authors | Davis, T.,Walker, J.R.,Mackenzie, F.,Weigelt, J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-01-21, release date: 2009-02-03, Last modification date: 2023-11-22) |
Primary citation | Davis, T.L.,Walker, J.R.,Allali-Hassani, A.,Parker, S.A.,Turk, B.E.,Dhe-Paganon, S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. Febs J., 276:4395-4404, 2009 Cited by PubMed: 19678838DOI: 10.1111/j.1742-4658.2009.07147.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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