3FW3

Crystal Structure of soluble domain of CA4 in complex with Dorzolamide

3FW3 の概要

• エントリーDOI: 10.2210/pdb3fw3/pdb
• 関連するPDBエントリー: 3F7B 3F7U
• 分子名称: Carbonic anhydrase 4, ZINC ION, (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, ... (6 entities in total)
• 機能のキーワード: structure-based drug design. small molecule complex. co-crystal, cell membrane, disease mutation, glycoprotein, gpi-anchor, lipoprotein, lyase, membrane, metal-binding, polymorphism, retinitis pigmentosa, sensory transduction, vision, zinc
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61880.93

構造登録者

Greasley, S.E.,Ferre, R.A.A.,Paz, R.,Wickersham, J. (登録日: 2009-01-16, 公開日: 2009-12-01, 最終更新日: 2023-09-06)

• 主引用文献: Vernier, W.,Chong, W.,Rewolinski, D.,Greasley, S.,Pauly, T.,Shaw, M.,Dinh, D.,Ferre, R.A.,Nukui, S.,Ornelas, M.,Reyner, E.; Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.; Bioorg.Med.Chem., 18:3307-3319, 2010; PubMed: 20363633; DOI: 10.1016/j.bmc.2010.03.014

実験手法

X-RAY DIFFRACTION (1.72 Å)