3F7U
Crystal Structure of soluble domain of CA4 in complex with small molecule.
Summary for 3F7U
Entry DOI | 10.2210/pdb3f7u/pdb |
Related | 3F7B 3FW3 |
Descriptor | Carbonic anhydrase 4, ZINC ION, N-(3-methoxypropyl)-2-(phenylsulfanyl)-5-sulfamoylpyridine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | structure-based drug design. small molecule complex. co-crystal., cell membrane, disease mutation, glycoprotein, gpi-anchor, lipoprotein, lyase, membrane, metal-binding, retinitis pigmentosa, sensory transduction, vision, zinc |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Lipid-anchor, GPI-anchor: P22748 |
Total number of polymer chains | 4 |
Total formula weight | 123245.41 |
Authors | Pauly, T.A.,Ferre, R.A.A.,Greasley, S.E.,Paz, R. (deposition date: 2008-11-10, release date: 2009-09-22, Last modification date: 2024-04-03) |
Primary citation | Vernier, W.,Chong, W.,Rewolinski, D.,Greasley, S.,Pauly, T.,Shaw, M.,Dinh, D.,Ferre, R.A.,Nukui, S.,Ornelas, M.,Reyner, E. Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. Bioorg.Med.Chem., 18:3307-3319, 2010 Cited by PubMed: 20363633DOI: 10.1016/j.bmc.2010.03.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report