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3F7U

Crystal Structure of soluble domain of CA4 in complex with small molecule.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004089molecular_functioncarbonate dehydratase activity
A0005515molecular_functionprotein binding
A0005791cellular_componentrough endoplasmic reticulum
A0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
A0005794cellular_componentGolgi apparatus
A0005802cellular_componenttrans-Golgi network
A0005886cellular_componentplasma membrane
A0006730biological_processone-carbon metabolic process
A0008270molecular_functionzinc ion binding
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0015701biological_processbicarbonate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016829molecular_functionlyase activity
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031526cellular_componentbrush border membrane
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0070062cellular_componentextracellular exosome
A0098552cellular_componentside of membrane
B0004089molecular_functioncarbonate dehydratase activity
B0005515molecular_functionprotein binding
B0005791cellular_componentrough endoplasmic reticulum
B0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
B0005794cellular_componentGolgi apparatus
B0005802cellular_componenttrans-Golgi network
B0005886cellular_componentplasma membrane
B0006730biological_processone-carbon metabolic process
B0008270molecular_functionzinc ion binding
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0015701biological_processbicarbonate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016829molecular_functionlyase activity
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031526cellular_componentbrush border membrane
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0070062cellular_componentextracellular exosome
B0098552cellular_componentside of membrane
C0004089molecular_functioncarbonate dehydratase activity
C0005515molecular_functionprotein binding
C0005791cellular_componentrough endoplasmic reticulum
C0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
C0005794cellular_componentGolgi apparatus
C0005802cellular_componenttrans-Golgi network
C0005886cellular_componentplasma membrane
C0006730biological_processone-carbon metabolic process
C0008270molecular_functionzinc ion binding
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0015701biological_processbicarbonate transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016324cellular_componentapical plasma membrane
C0016829molecular_functionlyase activity
C0030658cellular_componenttransport vesicle membrane
C0030667cellular_componentsecretory granule membrane
C0031526cellular_componentbrush border membrane
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0070062cellular_componentextracellular exosome
C0098552cellular_componentside of membrane
D0004089molecular_functioncarbonate dehydratase activity
D0005515molecular_functionprotein binding
D0005791cellular_componentrough endoplasmic reticulum
D0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
D0005794cellular_componentGolgi apparatus
D0005802cellular_componenttrans-Golgi network
D0005886cellular_componentplasma membrane
D0006730biological_processone-carbon metabolic process
D0008270molecular_functionzinc ion binding
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0015701biological_processbicarbonate transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016324cellular_componentapical plasma membrane
D0016829molecular_functionlyase activity
D0030658cellular_componenttransport vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0031526cellular_componentbrush border membrane
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0070062cellular_componentextracellular exosome
D0098552cellular_componentside of membrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 260
ChainResidue
AHIS94
AHIS96
AHIS119
AAG4265

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE AG4 A 265
ChainResidue
AHIS96
AHIS119
AVAL121
ALEU198
ATHR199
ATHR200
ATRP209
AZN260
AASN62
AHIS64
ASER65
AGLN92
AHIS94

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 261
ChainResidue
BHIS94
BHIS96
BHIS119
BAG4266

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE AG4 B 266
ChainResidue
BASN62
BHIS64
BSER65
BGLN92
BHIS94
BHIS96
BHIS119
BILE141
BLEU198
BTHR199
BTHR200
BTRP209
BZN261

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 262
ChainResidue
CHIS94
CHIS96
CHIS119
CAG4267

site_idAC6
Number of Residues14
DetailsBINDING SITE FOR RESIDUE AG4 C 267
ChainResidue
CASN62
CHIS64
CSER65
CGLN92
CHIS94
CHIS96
CHIS119
CVAL121
CGLU123
CVAL143
CLEU198
CTHR199
CTHR200
CZN262

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 263
ChainResidue
DHIS94
DHIS96
DHIS119
DAG4268

site_idAC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE AG4 D 268
ChainResidue
DASN62
DHIS64
DSER65
DGLN92
DHIS94
DHIS96
DHIS119
DVAL121
DGLU123
DILE141
DLEU198
DTHR199
DTHR200
DZN263

Functional Information from PROSITE/UniProt
site_idPS00162
Number of Residues17
DetailsALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHsLdgehFamEMHIV
ChainResidueDetails
ASER105-VAL121

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P00918
ChainResidueDetails
AHIS64
BHIS64
CHIS64
DHIS64

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:8942978
ChainResidueDetails
AHIS94
DHIS94
DHIS96
DHIS119
AHIS96
AHIS119
BHIS94
BHIS96
BHIS119
CHIS94
CHIS96
CHIS119

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00918
ChainResidueDetails
ATHR199
BTHR199
CTHR199
DTHR199

site_idSWS_FT_FI4
Number of Residues4
DetailsLIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:7625839
ChainResidueDetails
ASER259
BSER259
CSER259
DSER259

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ca2
ChainResidueDetails
ATHR199
AHIS64

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ca2
ChainResidueDetails
BTHR199
BHIS64

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ca2
ChainResidueDetails
CTHR199
CHIS64

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ca2
ChainResidueDetails
DTHR199
DHIS64

224201

PDB entries from 2024-08-28

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