3F7U

Crystal Structure of soluble domain of CA4 in complex with small molecule.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0005515	molecular_function	protein binding
A	0005791	cellular_component	rough endoplasmic reticulum
A	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016829	molecular_function	lyase activity
A	0030658	cellular_component	transport vesicle membrane
A	0030667	cellular_component	secretory granule membrane
A	0031526	cellular_component	brush border membrane
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0070062	cellular_component	extracellular exosome
A	0098552	cellular_component	side of membrane
B	0004089	molecular_function	carbonate dehydratase activity
B	0005515	molecular_function	protein binding
B	0005791	cellular_component	rough endoplasmic reticulum
B	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0005886	cellular_component	plasma membrane
B	0008270	molecular_function	zinc ion binding
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0015701	biological_process	bicarbonate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0016829	molecular_function	lyase activity
B	0030658	cellular_component	transport vesicle membrane
B	0030667	cellular_component	secretory granule membrane
B	0031526	cellular_component	brush border membrane
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070062	cellular_component	extracellular exosome
B	0098552	cellular_component	side of membrane
C	0004089	molecular_function	carbonate dehydratase activity
C	0005515	molecular_function	protein binding
C	0005791	cellular_component	rough endoplasmic reticulum
C	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
C	0005794	cellular_component	Golgi apparatus
C	0005802	cellular_component	trans-Golgi network
C	0005886	cellular_component	plasma membrane
C	0008270	molecular_function	zinc ion binding
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0015701	biological_process	bicarbonate transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0016324	cellular_component	apical plasma membrane
C	0016829	molecular_function	lyase activity
C	0030658	cellular_component	transport vesicle membrane
C	0030667	cellular_component	secretory granule membrane
C	0031526	cellular_component	brush border membrane
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0070062	cellular_component	extracellular exosome
C	0098552	cellular_component	side of membrane
D	0004089	molecular_function	carbonate dehydratase activity
D	0005515	molecular_function	protein binding
D	0005791	cellular_component	rough endoplasmic reticulum
D	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
D	0005794	cellular_component	Golgi apparatus
D	0005802	cellular_component	trans-Golgi network
D	0005886	cellular_component	plasma membrane
D	0008270	molecular_function	zinc ion binding
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0015701	biological_process	bicarbonate transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0016324	cellular_component	apical plasma membrane
D	0016829	molecular_function	lyase activity
D	0030658	cellular_component	transport vesicle membrane
D	0030667	cellular_component	secretory granule membrane
D	0031526	cellular_component	brush border membrane
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0070062	cellular_component	extracellular exosome
D	0098552	cellular_component	side of membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 260

Chain	Residue
A	HIS94
A	HIS96
A	HIS119
A	AG4265

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AG4 A 265

Chain	Residue
A	HIS96
A	HIS119
A	VAL121
A	LEU198
A	THR199
A	THR200
A	TRP209
A	ZN260
A	ASN62
A	HIS64
A	SER65
A	GLN92
A	HIS94

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 261

Chain	Residue
B	HIS94
B	HIS96
B	HIS119
B	AG4266

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AG4 B 266

Chain	Residue
B	ASN62
B	HIS64
B	SER65
B	GLN92
B	HIS94
B	HIS96
B	HIS119
B	ILE141
B	LEU198
B	THR199
B	THR200
B	TRP209
B	ZN261

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 262

Chain	Residue
C	HIS94
C	HIS96
C	HIS119
C	AG4267

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AG4 C 267

Chain	Residue
C	ASN62
C	HIS64
C	SER65
C	GLN92
C	HIS94
C	HIS96
C	HIS119
C	VAL121
C	GLU123
C	VAL143
C	LEU198
C	THR199
C	THR200
C	ZN262

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 263

Chain	Residue
D	HIS94
D	HIS96
D	HIS119
D	AG4268

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AG4 D 268

Chain	Residue
D	ASN62
D	HIS64
D	SER65
D	GLN92
D	HIS94
D	HIS96
D	HIS119
D	VAL121
D	GLU123
D	ILE141
D	LEU198
D	THR199
D	THR200
D	ZN263

---

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHsLdgehFamEMHIV

Chain	Residue	Details
A	SER105-VAL121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8942978","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Lipidation: {"description":"GPI-anchor amidated serine","evidences":[{"source":"PubMed","id":"7625839","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ca2

Chain	Residue	Details
A	THR199
A	HIS64

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ca2

Chain	Residue	Details
B	THR199
B	HIS64

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ca2

Chain	Residue	Details
C	THR199
C	HIS64

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ca2

Chain	Residue	Details
D	THR199
D	HIS64

---