3FW3

Crystal Structure of soluble domain of CA4 in complex with Dorzolamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0005515	molecular_function	protein binding
A	0005791	cellular_component	rough endoplasmic reticulum
A	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0005886	cellular_component	plasma membrane
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016829	molecular_function	lyase activity
A	0030658	cellular_component	transport vesicle membrane
A	0030667	cellular_component	secretory granule membrane
A	0031526	cellular_component	brush border membrane
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0070062	cellular_component	extracellular exosome
A	0098552	cellular_component	side of membrane
B	0004089	molecular_function	carbonate dehydratase activity
B	0005515	molecular_function	protein binding
B	0005791	cellular_component	rough endoplasmic reticulum
B	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0005886	cellular_component	plasma membrane
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0015701	biological_process	bicarbonate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0016829	molecular_function	lyase activity
B	0030658	cellular_component	transport vesicle membrane
B	0030667	cellular_component	secretory granule membrane
B	0031526	cellular_component	brush border membrane
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070062	cellular_component	extracellular exosome
B	0098552	cellular_component	side of membrane

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHsLdgehFamEMHIV

Chain	Residue	Details
A	SER105-VAL121

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P00918

Chain	Residue	Details
A	HIS64
B	HIS64

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:8942978

Chain	Residue	Details
A	HIS94
A	HIS96
A	HIS119
B	HIS94
B	HIS96
B	HIS119

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00918

Chain	Residue	Details
A	THR199
B	THR199

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site_id	SWS_FT_FI4
Number of Residues	2
Details	LIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:7625839

Chain	Residue	Details
A	SER259
B	SER259

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ca2

Chain	Residue	Details
A	THR199
A	HIS64

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ca2

Chain	Residue	Details
B	THR199
B	HIS64

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