3FUG

Crystal Structure of the Retinoid X Receptor Ligand Binding Domain Bound to the Synthetic Agonist 3-[4-Hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-phenyl]acrylic Acid

3FUG の概要

• エントリーDOI: 10.2210/pdb3fug/pdb
• 関連するPDBエントリー: 2p1t 2p1u 2p1v
• 分子名称: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E)-3-[4-hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]prop-2-enoic acid, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, hormone receptor, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, activator, phosphoprotein, transcription-transcription regulator complex, transcription/transcription regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P19793 Q15596
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28756.37

構造登録者

Bourguet, W. (登録日: 2009-01-14, 公開日: 2009-05-12, 最終更新日: 2023-09-06)

• 主引用文献: Perez Santin, E.,Germain, P.,Quillard, F.,Khanwalkar, H.,Rodriguez-Barrios, F.,Gronemeyer, H.,de Lera, A.R.,Bourguet, W.; Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.; J.Med.Chem., 52:3150-3158, 2009; PubMed: 19408900; DOI: 10.1021/jm900096q

実験手法

X-RAY DIFFRACTION (2 Å)