3FSU

Crystal Structure of Escherichia coli Methylenetetrahydrofolate Reductase Double Mutant Phe223LeuGlu28Gln complexed with methyltetrahydrofolate

Summary for 3FSU

• Entry DOI: 10.2210/pdb3fsu/pdb
• Related: 3FST
• Descriptor: 5,10-methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, ... (6 entities in total)
• Functional Keywords: tim barrel, flavin, reductase, methyltetrahydrofolate, amino-acid biosynthesis, fad, flavoprotein, methionine biosynthesis, nad, nadp, oxidoreductase
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 3
• Total formula weight: 106036.30

Authors

Tanner, J.J. (deposition date: 2009-01-12, release date: 2009-08-25, Last modification date: 2023-09-06)

• Primary citation: Lee, M.N.,Takawira, D.,Nikolova, A.P.,Ballou, D.P.,Furtado, V.C.,Phung, N.L.,Still, B.R.,Thorstad, M.K.,Tanner, J.J.,Trimmer, E.E.; Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli.; Biochemistry, 48:7673-7685, 2009; PubMed: 19610625; DOI: 10.1021/bi9007325

Experimental method

X-RAY DIFFRACTION (1.7 Å)