3FST

Crystal Structure of Escherichia coli Methylenetetrahydrofolate Reductase Mutant Phe223Leu at pH 7.4

Summary for 3FST

Entry DOI	10.2210/pdb3fst/pdb
Related	3FSU
Descriptor	5,10-methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, MESO-ERYTHRITOL, ... (5 entities in total)
Functional Keywords	tim barrel, flavin, reductase, amino-acid biosynthesis, fad, flavoprotein, methionine biosynthesis, nad, nadp, oxidoreductase
Biological source	Escherichia coli K-12
Total number of polymer chains	3
Total formula weight	105312.47
Authors	Tanner, J.J. (deposition date: 2009-01-12, release date: 2009-08-25, Last modification date: 2023-09-06)
Primary citation	Lee, M.N.,Takawira, D.,Nikolova, A.P.,Ballou, D.P.,Furtado, V.C.,Phung, N.L.,Still, B.R.,Thorstad, M.K.,Tanner, J.J.,Trimmer, E.E. Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli. Biochemistry, 48:7673-7685, 2009 Cited by PubMed: 19610625 DOI: 10.1021/bi9007325 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation