3FSI

Crystal structure of a trypanocidal 4,4'-Bis(imidazolinylamino)diphenylamine bound to DNA

Summary for 3FSI

DescriptorReverse transcriptase domain, 5'-D(*CP*TP*TP*AP*AP*TP*TP*C)-3', 5'-D(P*GP*AP*AP*TP*TP*AP*AP*G)-3', ... (6 entities in total)
Functional Keywordstransferase/dna mmlv rt, protein-dna complex, drug-dna complex, cd27, antitrypanosomal, dna integration, dna recombination, nucleotidyltransferase, transferase, transferase-dna complex, transferase/dna
Biological sourceMoloney murine leukemia virus (Virus)
Cellular locationGag-Pol polyprotein: Host cell membrane ; Lipid-anchor . Matrix protein p15: Virion . Capsid protein p30: Virion . Nucleocapsid protein p10: Virion  P03355
Total number of polymer chains3
Total molecular weight34416.17
Authors
Glass, L.S.,Georgiadis, M.M.,Goodwin, K.D. (deposition date: 2009-01-09, release date: 2009-05-19, Last modification date: 2017-11-01)
Primary citation
Glass, L.S.,Nguyen, B.,Goodwin, K.D.,Dardonville, C.,Wilson, W.D.,Long, E.C.,Georgiadis, M.M.
Crystal structure of a trypanocidal 4,4'-bis(imidazolinylamino)diphenylamine bound to DNA.
Biochemistry, 48:5943-5952, 2009
PubMed: 19405506 (PDB entries with the same primary citation)
DOI: 10.1021/bi900204w
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.75 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers121.2%1.4%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3fsi
no rotation
Molmil generated image of 3fsi
rotated about x axis by 90°
Molmil generated image of 3fsi
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3fsi
no rotation
Molmil generated image of 3fsi
rotated about x axis by 90°
Molmil generated image of 3fsi
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3fsi.pdb1.gz [105.41 KB])