3FS1

Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment

Summary for 3FS1

Entry DOI	10.2210/pdb3fs1/pdb
Related	1PZL
Descriptor	Hepatocyte nuclear factor 4-alpha, PPARgamma Coactivator-1a (PGC-1a), MYRISTIC ACID, ... (4 entities in total)
Functional Keywords	nuclear receptor, coactivator, lxxll motif, mody, diabetes, alternative promoter usage, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P41235
Total number of polymer chains	2
Total formula weight	27005.58
Authors	Rha, G.,Wu, G.,Chi, Y. (deposition date: 2009-01-08, release date: 2009-10-27, Last modification date: 2023-09-06)
Primary citation	Rha, G.B.,Wu, G.,Shoelson, S.E.,Chi, Y.I. Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation J.Biol.Chem., 284:35165-35176, 2009 Cited by PubMed: 19846556 DOI: 10.1074/jbc.M109.052506 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation