3FS1

Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003323	biological_process	type B pancreatic cell development
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0050796	biological_process	regulation of insulin secretion
A	0055088	biological_process	lipid homeostasis
A	0070365	biological_process	hepatocyte differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MYR A 500

Chain	Residue
A	HOH21
A	SER181
A	GLN185
A	ALA223
A	ARG226
A	LEU236
A	GLY237
A	MET252
A	ILE346

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:21708125

Chain	Residue	Details
A	THR157

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:21708125

Chain	Residue	Details
A	SER158

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:12740371

Chain	Residue	Details
A	SER304

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site_id	SWS_FT_FI4
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21708125

Chain	Residue	Details
A	LYS225
A	LYS298

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