3FRF
S. aureus DHFR complexed with NADPH and iclaprim
Summary for 3FRF
Entry DOI | 10.2210/pdb3frf/pdb |
Related | 3FRA 3FRB 3FRD 3FRE |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, ... (4 entities in total) |
Functional Keywords | dhfr, oxidoreductase, nadp, one-carbon metabolism |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 19244.56 |
Authors | Oefner, C.,Dale-Glenn, E. (deposition date: 2009-01-08, release date: 2010-01-12, Last modification date: 2024-03-20) |
Primary citation | Oefner, C.,Bandera, M.,Haldimann, A.,Laue, H.,Schulz, H.,Mukhija, S.,Parisi, S.,Weiss, L.,Lociuro, S.,Dale, G.E. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity J.Antimicrob.Chemother., 63:687-698, 2009 Cited by PubMed: 19211577DOI: 10.1093/jac/dkp024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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